RIFM fragrance ingredient safety assessment, 1,1-diethoxy-3,5,5-trimethylhexane, CAS registry number 86198-35-8

1, 1-Diethoxy-3,5,5-trimethylhexane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-methylundecanal dimethyl acetal (CAS # 68141-17-3) show that 1,1-diethoxy-3,5,5-trimethylhexane is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1,1-diethoxy-3,5,5-trimethylhexane is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from read-across analog hydroxycitronellal dimethyl acetal (CAS # 141-92-4) show that there are no safety concerns for 1,1-diethoxy-3,5,5-trimethylhexane for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1,1-diethoxy-3,5,5-trimethylhexane is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; for the hazard assessment based on the screening data, 1,1-diethoxy-3,5,5-trimethylhexane is not Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, 1,1-diethoxy-3,5,5-trimethylhexane was not able to be risk screened as there were no reported volumes of use (VoU) for either North America or Europe in the 2019 IFRA Survey.