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RIFM fragrance ingredient safety assessment, 1,1-diethoxy-3,5,5-trimethylhexane, CAS registry number 86198-35-8
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Summary
This safety assessment found 1,1-diethoxy-3,5,5-trimethylhexane to be safe for genotoxicity, skin sensitization, and photoirritation. Environmental safety evaluations indicate it is not Persistent, Bioaccumulative, and Toxic (PBT).
Area of Science:
- Toxicology and Environmental Safety Assessment
- Chemical Safety and Risk Evaluation
- Fragrance Ingredient Safety
Background:
- 1,1-Diethoxy-3,5,5-trimethylhexane is a chemical compound requiring comprehensive safety evaluation.
- Previous assessments have utilized read-across data from analogous substances to predict toxicological profiles.
- Understanding the safety of fragrance ingredients is crucial for consumer products.
Purpose of the Study:
- To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety of 1,1-diethoxy-3,5,5-trimethylhexane.
- To determine if exposure levels are below the Threshold of Toxicological Concern (TTC) for relevant toxicity endpoints.
- To assess the environmental hazard and risk profile according to International Fragrance Association (IFRA) standards.
Main Methods:
- Genotoxicity was assessed using read-across data from 2-methylundecanal dimethyl acetal.
- Repeated dose, reproductive, and local respiratory toxicity were evaluated against the Threshold of Toxicological Concern (TTC) for Cramer Class I materials.
- Skin sensitization was evaluated using read-across data from hydroxycitronellal dimethyl acetal, and photoirritation/photoallergenicity was assessed via UV/Vis spectra.
Main Results:
- 1,1-Diethoxy-3,5,5-trimethylhexane is not expected to be genotoxic, nor is it expected to be photoirritating or photoallergenic.
- Exposure levels for repeated dose, reproductive, and local respiratory toxicity were found to be below the TTC.
- No safety concerns for skin sensitization were identified at current usage levels; the substance is not Persistent, Bioaccumulative, and Toxic (PBT).
Conclusions:
- 1,1-Diethoxy-3,5,5-trimethylhexane demonstrates a favorable safety profile across multiple toxicological endpoints.
- The compound is considered safe for use concerning genotoxicity, skin sensitization, photoirritation, and environmental persistence.
- Further risk assessment for environmental safety is limited by the absence of reported volumes of use in recent surveys.
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