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Related Experiment Video

Updated: Apr 26, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
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Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

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Meta-analysis: low-dose intake of vitamin E combined with other vitamins or minerals may decrease all-cause

Shan Jiang1, Zhenyu Pan, Hui Li

  • 1Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine.

Journal of Nutritional Science and Vitaminology
|August 1, 2014
PubMed
Summary
This summary is machine-generated.

Vitamin E alone does not reduce mortality. However, low-dose vitamin E (under 400 IU/d) combined with other agents significantly lowers all-cause mortality, especially in healthy individuals.

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Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
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Area of Science:

  • Nutritional Science
  • Preventive Medicine
  • Clinical Trials

Background:

  • Oxidative stress is implicated in chronic diseases like cardiovascular disease and cancer.
  • Vitamin E is hypothesized to prevent oxidative stress and related diseases.

Purpose of the Study:

  • To evaluate the effect of vitamin E supplementation on all-cause mortality.
  • To assess vitamin E alone versus combined with other agents.

Main Methods:

  • Meta-analysis of 33 randomized controlled trials.
  • Searched PubMed/MEDLINE, EMBASE, and Cochrane Library.
  • Used relative risk (RR) to compare intervention and control groups.

Main Results:

  • Vitamin E alone showed no significant effect on all-cause mortality (RR=1.01).
  • Vitamin E combined with other agents did not significantly reduce mortality (RR=0.97).
  • Low-dose vitamin E (<400 IU/d) with other agents significantly reduced mortality (RR=0.92).
  • Vitamin E with other agents reduced mortality in individuals without pre-existing diseases (RR=0.92).

Conclusions:

  • Vitamin E supplementation alone is not associated with reduced mortality.
  • Low-dose vitamin E (<400 IU/d) in combination with other agents shows a significant mortality benefit.
  • Combined vitamin E and other agents may be beneficial for mortality reduction in healthy populations.