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Association between miR-27a genetic variants and susceptibility to colorectal cancer

Zaiqiu Wang, Xiaoli Sun, Yeli Wang

  • 1Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China. prhusanyuan@163.com.

Diagnostic Pathology
|August 1, 2014
PubMed
Abstract

Insights

The rs895819 polymorphism in microRNA-27a (miR-27a) is linked to increased colorectal cancer (CRC) risk, particularly the GG genotype. This genetic variation may also correlate with a higher likelihood of CRC metastasis.

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • Single nucleotide polymorphisms (SNPs) in miRNAs can affect their function and are implicated in cancer.
  • The pre-miR-27a rs895819 polymorphism has been previously associated with various cancers.

Purpose of the Study:

  • To investigate the association between the rs895819 polymorphism in pre-microRNA-27a (pre-miR-27a) and susceptibility to colorectal cancer (CRC).
  • To evaluate the potential impact of this polymorphism on CRC risk and metastasis.

Main Methods:

  • A case-control study was conducted involving 205 CRC patients and 455 healthy controls.
  • Genotyping for the rs895819 single nucleotide polymorphism (SNP) in pre-miR-27a was performed.

Main Results:

  • The GG genotype of rs895819 was significantly associated with an increased risk of CRC compared to the AA genotype (OR 1.599, 95% CI: 1.052 - 2.430).
  • No significant association was found between the AG genotype and CRC risk.
  • Both the GG genotype and the G allele were significantly associated with an increased risk of metastasis in CRC patients (P < 0.001 and P = 0.003, respectively).

Conclusions:

  • The rs895819 polymorphism in pre-miR-27a is significantly associated with colorectal cancer risk.
  • Further large-scale, population-based studies are warranted to confirm these findings and explore the role of miR-27a polymorphism in CRC susceptibility and severity.

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