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Updated: Apr 26, 2026

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins
Published on: August 31, 2017
Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41
Guanghui Shen1, Kezhen Wang1, Shuai Wang1
1Soochow University, Institutes of Biology and Medical Sciences, Suzhou, China.
Abstract:
The interferon (IFN)-inducible viperin protein restricts a broad range of viruses. However, whether viperin plays a role during herpes simplex virus 1 (HSV-1) infection is poorly understood. In the present study, it was shown for the first time that wild-type (WT) HSV-1 infection couldn't induce viperin production, and ectopically expressed viperin inhibited the replication of UL41-null HSV-1 but not WT viruses. The underlying molecular mechanism is that UL41 counteracts viperin's antiviral activity by reducing its mRNA accumulation.
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