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[Hypertrophic protein-losing gastropathy: Ménétrier disease. A clinical case]

Arturo Kirberg B, Briny Rodríguez V, Francisco Donoso V

    Revista Chilena De Pediatria
    |August 1, 2014
    PubMed
    Abstract

    Insights

    Pediatric Ménétrier disease, a rare protein-losing gastropathy, presents with edema. This case highlights the link between this condition and infections like Cytomegalovirus (CMV) and Helicobacter pylori (H. pylori).

    Area of Science:

    • Pediatric Gastroenterology
    • Rare Diseases
    • Gastrointestinal Disorders

    Background:

    • Ménétrier disease is a rare disorder causing gastric foveolar hyperplasia and protein loss.
    • In children, it manifests as edema without renal or hepatic issues, often linked to Cytomegalovirus (CMV) or Helicobacter pylori (H. pylori) infections.

    Observation:

    • A five-year-old child presented with generalized edema, abdominal pain, and malaise.
    • Endoscopy revealed severe gastric mucosa compromise, with positive tests for H. pylori and CMV.

    Findings:

    • The patient received albumin and H2 receptor antagonists, showing a favorable outcome.
    • An 8-month follow-up endoscopy confirmed the absence of abnormalities, indicating spontaneous remission.

    Implications:

    • Diagnosis of hypertrophic protein-losing gastropathy can be supported by clinical presentation and endoscopy.
    • Further research is needed to establish a definitive association between Ménétrier disease and CMV/H. pylori infections in a larger pediatric cohort.

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