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Updated: Apr 26, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Basal-Cell Carcinoma Occurring in Cutaneous Infundibular Cysts: Report of 2 Cases and Review of the Literature
Olga Udovenko1, Ying Guo, Thomas Connelly
1*New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY; †Ackerman Academy of Dermatopathology, New York, NY; and ‡Connelly Skin Cancer Surgery Center, Stuart, FL.
Abstract:
Cysts lined by stratified squamous epithelium indistinguishable from the epidermis, referred to as epidermoid cysts, epidermal inclusion cysts, and infundibular cysts, are the most common type of cyst occurring in the skin. They are invariably benign, and malignant neoplasms arising within the wall of such cysts are distinctly uncommon. Even basal-cell carcinoma, which is the most common cutaneous malignant neoplasm of the skin, has rarely been reported to occur in association with epidermoid cysts. The authors report their experience studying 2 patients with basal-cell carcinoma arising in association with an epidermoid cyst. These cases highlight the need to examine, histopathologically, tissue from this common and usually benign lesion. The authors also review the medical literature.
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