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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Related Experiment Video

Updated: Apr 26, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Optical coherence tomography today: speed, contrast, and multimodality.

Wolfgang Drexler, Mengyang Liu, Abhishek Kumar

    Journal of Biomedical Optics
    |August 1, 2014
    PubMed
    Summary

    Optical coherence tomography (OCT) has seen major advancements in resolution and speed over 25 years, becoming a vital clinical imaging tool. Innovations like swept source lasers and parallel detection enhance its capabilities for various applications.

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    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Translational Optical Imaging

    Background:

    • Optical coherence tomography (OCT) has significantly evolved over the past 25 years.
    • It has achieved substantial clinical acceptance and economic impact due to technological advancements.

    Purpose of the Study:

    • To review the advancements in optical coherence tomography (OCT) technology.
    • To highlight improvements in resolution, imaging speed, and novel applications.
    • To discuss the integration of OCT with other imaging modalities.

    Main Methods:

    • Review of state-of-the-art swept source laser technologies.
    • Discussion of parallelized OCT detection methods (line-field and full-field OCT).
    • Exploration of functional and contrast-enhancing OCT applications, including label-free angiography.
    • Review of multimodal imaging modalities incorporating OCT.

    Main Results:

    • Resolution improvements by a factor of 10 to the submicron regime.
    • Imaging speed increases exceeding 5 million A-scans per second.
    • Development of quasi-akinetic scanning through parallelized OCT detection.
    • Demonstration of label-free angiography as a promising functional OCT application.

    Conclusions:

    • OCT has undergone transformative advancements, enhancing its clinical utility.
    • Technological innovations continue to expand the capabilities and applications of OCT.
    • Multimodal imaging approaches synergistically address OCT's limitations, offering comprehensive diagnostic potential.