Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diazepam induces a dissociation between explicit and implicit memory.

J M Danion1, M A Zimmermann, D Willard-Schroeder

  • 1Clinique Psuchiatrique, Hospices Civils, Strasbourg, France.

Psychopharmacology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe metabolic acidosis due to acetazolamide intoxication in a dog.

Australian veterinary journal·2020
Same author

An Interventional Study Using Cell-Mediated Immunity to Personalize Therapy for Cytomegalovirus Infection After Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Benzodiazepine long-term administration is associated with impaired attention/working memory in schizophrenia: results from the national multicentre FACE-SZ data set.

European archives of psychiatry and clinical neuroscience·2017
Same author

Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset.

Schizophrenia research·2015
Same author

Lung transplantation with donation after circulatory determination of death donors and the impact of ex vivo lung perfusion.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Improved upper limits on the stochastic gravitational-wave background from 2009-2010 LIGO and Virgo data.

Physical review letters·2014
Same journal

Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis.

Psychopharmacology·2026
Same journal

GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.

Psychopharmacology·2026
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
See all related articles

Diazepam (0.2 mg/kg) impairs explicit memory recall but not implicit or knowledge memory in healthy adults. This drug-induced dissociation supports distinct memory systems, similar to amnesia.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • Understanding memory systems is crucial for neuroscience and psychology.
  • Diazepam is known to affect cognitive functions, but its specific impact on different memory types requires further elucidation.

Purpose of the Study:

  • To investigate the effects of diazepam on explicit, implicit, and knowledge memory.
  • To determine if diazepam causes a dissociation between different memory systems.

Main Methods:

  • A double-blind study involving 24 healthy volunteers.
  • Administered 0.2 mg/kg oral diazepam or placebo.
  • Assessed memory using free recall, word-stem completion, and category-generation tasks.

Main Results:

Related Experiment Videos

  • Diazepam significantly impaired explicit memory performance.
  • Implicit memory and knowledge memory remained unaffected by diazepam.
  • Explicit memory impairment correlated with diazepam-induced sedation and word affective load.

Conclusions:

  • Diazepam selectively impairs explicit memory while sparing implicit and knowledge memory.
  • The findings support the existence of distinct memory systems in the brain.
  • This dissociation mirrors memory deficits observed in organic amnesia.