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Salicylic acid (SA) bioaccessibility from SA-based poly(anhydride-ester).
Michael A Rogers1, Yim-Fan Yan, Karen Ben-Elazar
1Department of Food Science and †New Jersey Institute of Food, Nutrition and Health, Rutgers University, The State University of New Jersey , New Brunswick, New Jersey 08901, United States.
Biomacromolecules
|August 2, 2014
Summary
Incorporating salicylic acid (SA) into poly(anhydride-esters) significantly reduced its bioaccessibility after simulated digestion. This polymer modification offers a method to control drug release for therapeutic applications.
Area of Science:
- Polymer chemistry
- Pharmacology
- Drug delivery systems
Background:
- Salicylic acid (SA) is a widely used pharmaceutical compound.
- Controlling the bioaccessibility and release rate of SA is crucial for optimizing its therapeutic efficacy and minimizing side effects.
- Poly(anhydride-esters) offer a versatile platform for drug encapsulation and controlled release.
Purpose of the Study:
- To investigate the effect of incorporating salicylic acid (SA) into poly(anhydride-esters) on its bioaccessibility.
- To characterize the release kinetics of SA from the developed polymer system.
- To understand the factors influencing SA release from the polymer matrix.
Main Methods:
- Preparation of poly(anhydride-esters) incorporating salicylic acid (SA).
- Simulated digestion studies to assess SA bioaccessibility.
- Analysis of SA release rates and identification of influencing factors.
- Statistical analysis of bioaccessibility data.
Main Results:
- Bioaccessibility of SA was significantly reduced when incorporated into poly(anhydride-esters) compared to free SA.
- SA bioaccessibility was 55.5 ± 2.0% for free SA, 31.2 ± 2.4% for the SA-diglycolic acid polymer precursor (SADG), and 21.2 ± 3.1% for the SADG-P polymer.
- SA release followed a zero-order kinetics, influenced by solubilization, polymer erosion, and hydrolytic cleavage of anhydride bonds and the polymer precursor.
Conclusions:
- Poly(anhydride-esters) effectively modify the bioaccessibility of salicylic acid (SA).
- The developed polymer system demonstrates controlled release of SA, with potential applications in drug delivery.
- Understanding the release mechanisms is key to designing advanced SA formulations.
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