Opioid formulations with sequestered naltrexone: a perspective review
Robert Taylor1, Robert B Raffa2, Joseph V Pergolizzi3
1NEMA Research Inc., 840 111 Ave N, #9 Naples, FL 34108, USA.
Therapeutic Advances in Drug Safety
|August 2, 2014
Summary
Opioid prescribing increased significantly, leading to concerns about misuse. Abuse-deterrent opioid formulations aim to balance effective pain management with reduced risks, forming part of a comprehensive opioid risk management plan.
Area of Science:
- Pain Management
- Pharmacology
- Public Health
Background:
- Opioid prescribing surged over the last decade to address pain undertreatment.
- This increase is linked to rising rates of prescription opioid misuse, abuse, morbidity, and mortality.
- Despite risks, opioids remain crucial for pain management within comprehensive strategies.
Purpose of the Study:
- To review major abuse-deterrent strategies (formulations) for opioids.
- To emphasize balancing effective pain management with appropriate opioid use.
- To highlight the role of these strategies in opioid risk management.
Main Methods:
- Review of existing and developing abuse-deterrent opioid formulations.
- Analysis of the role of these formulations in addressing diversion and abuse.
- Consideration of these strategies within universal prescribing precautions and risk management plans.
Main Results:
- Several major abuse-deterrent opioid formulations have been developed.
- These formulations represent a step towards mitigating opioid diversion and abuse.
- They are intended to be part of a broader opioid risk management approach.
Conclusions:
- Abuse-deterrent opioid formulations are a key component in managing the risks associated with opioid therapy.
- These strategies aim to reduce misuse and abuse without discriminating against patients needing pain relief.
- Effective chronic pain management requires a balanced approach, incorporating abuse deterrence within a comprehensive risk management plan.
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