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Updated: Apr 26, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
Published on: November 12, 2019
CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
Sarah Tettamanti1, Andrea Biondi1, Ettore Biagi1
1Centro di Ricerca "Matilde Tettamanti"; Department of Pediatrics; San Gerardo Hospital; University of Milano-Bicocca; Monza, Italy.
Abstract:
Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we discuss how this genetically modified cell-based strategy could be relevant to the field of AML therapeutics.
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