Related Experiment Video

Updated: Apr 26, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
06:54

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

10.8K

LTX-315 (Oncopore™): A short synthetic anticancer peptide and novel immunotherapeutic agent

Ketil André Camilio1, Oystein Rekdal2, Baldur Sveinbjörnsson1

  • 1Lytix Biopharma AS; Tromsø, Norway ; Department of Medical Biology; Faculty of Health Sciences; University of Tromsø; Tromsø, Norway.

Oncoimmunology
|August 2, 2014
PubMed

Insights

A novel synthetic peptide, LTX-315, effectively eliminated B16 melanomas in mice. This peptide also triggered protective immune responses, suggesting potential for cancer immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Peptide Science

Background:

  • Cationic antimicrobial peptides (CAMPs) show potential as anticancer agents.
  • LTX-315 is a novel synthetic peptide with previously identified anticancer properties.

Purpose of the Study:

  • To evaluate the efficacy of LTX-315 against syngeneic B16 melanomas.
  • To investigate the immune responses induced by LTX-315.

Main Methods:

  • Intralesional administration of LTX-315 in a B16 melanoma mouse model.
  • Assessment of tumor regression and systemic immune responses.

Main Results:

  • LTX-315 treatment resulted in complete regression of B16 melanomas.
  • Intralesional LTX-315 induced systemic protective immune responses.

Conclusions:

  • LTX-315 demonstrates significant therapeutic potential for melanoma treatment.
  • The induction of immune responses suggests LTX-315 could be a valuable tool in cancer immunotherapy.
Keywords:
B16 melanomaDAMPsanticancer peptidesimmunogenic cell deathinflammationintralesional treatment

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

8.1K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

2.2K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.1K