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Updated: Apr 26, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Hormesis in cancer immunology: Does the quantity of an immune reactant matter?
Oliver Mt Pearce1, Heinz Läubli1, Jack Bui1
1Departments of Medicine, Pathology and Cellular and Molecular Medicine; Glycobiology Research and Training Center; University of California, San Diego; La Jolla, CA USA.
Abstract:
We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the potential clinical implications.
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