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Updated: Apr 26, 2026

High Pressure Single Crystal Diffraction at PX^2
Published on: January 16, 2017
Chance, destiny, and the inner workings of ClpXP
Rick Russell1, Andreas Matouschek1
1Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
Abstract:
AAA+ proteases are responsible for protein degradation in all branches of life. Using single-molecule and ensemble assays, Cordova et al. investigate how the bacterial protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic model that recapitulates the interplay between stochastic and deterministic behaviors of ClpXP.
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