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Simplified magnetic anchor-guided endoscopic submucosal dissection in dogs (with videos)
Ippei Matsuzaki1, Ryoji Miyahara1, Yoshiki Hirooka2
1Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Background:
Magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD) was developed to reduce adverse events such as bleeding and perforation and to facilitate ESD. However, the external electromagnet required miniaturization to make it suitable for daily clinical practice.
Objective:
To evaluate the feasibility of simplified MAG-ESD using permanent magnets.
Design:
Case series.
Setting:
Nagoya University Hospital.
Subjects:
Beagle dogs.
Interventions:
The simplified MAG-ESD was performed on 10 representative areas of the stomachs of beagle dogs. The magnetic anchor consisted of an internal magnet attached to a hemoclip. The external and internal magnets were made from the rare earth neodymium.
Main Outcome Measurements:
The feasibility of countertraction with good visualization using simplified MAG-ESD. The rate of perforation, the time required for preparation, and attaching the magnetic anchor were also evaluated.
Results:
All lesions were successfully resected without perforation. The magnetic anchor could be controlled easily, and direct visualization was maintained by adequate counter traction. Preparing the magnetic anchor and grasping the mucosal edge using the hemoclip was easy and required a median of only 4 minutes (range, 2-7 minutes).
Limitations:
Animal experiment, low number and lesion size.
Conclusions:
This simplified MAG-ESD is feasible and allowed excellent visualization in the dog stomach. The feasibility of this system should be assessed in humans.
