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Updated: Apr 26, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Precision medicine and precision therapeutics: hedgehog signaling pathway, basal cell carcinoma and beyond
Shalini V Mohan, Anne Lynn S Chang1
1Department of Dermatology, Stanford University School of Medicine, Redwood City, CA USA.
Abstract:
Precision medicine and precision therapeutics is currently in its infancy with tremendous potential to improve patient care by better identifying individuals at risk for skin cancer and predict tumor responses to treatment. This review focuses on the Hedgehog signaling pathway, its critical role in the pathogenesis of basal cell carcinoma, and the emergence of targeted treatments for advanced basal cell carcinoma. Opportunities to utilize precision medicine are outlined, such as molecular profiling to predict basal cell carcinoma response to targeted therapy and to inform therapeutic decisions.
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