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An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Published on: July 18, 2025

Perfusion imaging in liver MRI.

Choon Hua Thng¹, Tong San Koh², David Collins³

¹Duke-NUS Graduate Medical School, Singapore 169857, Republic of Singapore; Department of Oncologic Imaging, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Republic of Singapore.

Magnetic Resonance Imaging Clinics of North America

|August 4, 2014

Summary

Liver perfusion magnetic resonance (MR) imaging offers vital physiologic insights into liver tumors and surrounding tissue. This review details model-free and model-based MR imaging techniques for improved clinical decision-making in liver cancer therapy.

Keywords:

Cirrhosis Dynamic contrast enhancement Functional imaging Hepatocellular carcinoma Liver MR imaging Metastases Perfusion

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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

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Published on: May 30, 2011

Area of Science:

Radiology
Medical Imaging
Oncology

Background:

Liver perfusion magnetic resonance (MR) imaging is an emerging functional imaging technique.
It provides crucial physiologic data on liver microcirculation and tumor microenvironment.
Its importance is growing, especially for antiangiogenic therapy in liver cancers.

Purpose of the Study:

To review and compare model-free and model-based liver perfusion MR imaging approaches.
To discuss the clinical utility of different liver perfusion MR imaging methods.
To aid informed choices in performing liver perfusion MR imaging studies.

Main Methods:

Review of published literature on liver perfusion MR imaging.
Explanation of model-free and model-based analytical techniques.
Summary of strengths and weaknesses for each approach.

Main Results:

Detailed explanation of various liver perfusion MR imaging methodologies.
Comparison of the clinical applicability of different techniques.
Identification of relative strengths and limitations of each approach.

Conclusions:

Liver perfusion MR imaging is a valuable tool for assessing liver tumors.
Understanding different MR imaging models is key for optimal clinical application.
This review provides guidance for selecting appropriate liver perfusion MR imaging techniques.