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Updated: Apr 26, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
[Facial asymmetries and their skeletal component]
J-M Mercier1, J-P Perrin1, J Longis1
1Service de chirurgie maxillo-faciale et stomatologie, hôtel-Dieu, CHU, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
Facial asymmetries present complex challenges in orthognathic surgery, requiring thorough assessment of craniofacial structures and posture. Advanced imaging and computer-assisted techniques improve diagnosis and surgical outcomes for these challenging cases.
Area of Science:
- Orthognathic Surgery
- Craniofacial Surgery
- Plastic Surgery
Background:
- Facial asymmetries pose significant diagnostic and treatment challenges in orthognathic surgery.
- Management is complicated by soft tissue defects or basocranial asymmetry.
- Causes are diverse (congenital, constitutional, acquired) with substantial aesthetic, functional, and psychosocial impacts.
Purpose of the Study:
- To outline diagnostic and treatment strategies for complex facial asymmetries.
- To emphasize the importance of comprehensive clinical and radiographic evaluation.
- To discuss the role of advanced technologies in improving surgical outcomes.
Main Methods:
- Thorough clinical and radiographic examination, including patient posture.
- Mandatory diagnostic elements: anterior craniofacial cross and occlusal plane orientation.
- Utilizing 3D imaging and computer simulation for assessment and surgical planning.
Main Results:
- Standard orthognathic techniques are applicable, with specific considerations for vertical posterior dimension correction.
- 3D imaging enhances assessment of skeletal displacement during surgery.
- Traditional radiography remains valuable for pre- and postoperative comparisons.
Conclusions:
- Accurate diagnosis and treatment of facial asymmetries require a detailed craniofacial analysis.
- Computer-assisted surgery and 3D imaging offer potential for improved stability and results.
- Multifaceted approach is essential for managing complex facial deformities.
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