Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Breathing01:05

Breathing

50.2K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
50.2K
Micelles01:30

Micelles

353
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
353
Surface Active Agents01:27

Surface Active Agents

149
Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
149
Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

29
Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through...
29
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

4.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
4.7K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

3.1K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of patent ductus arteriosus - Evidence to practice.

Seminars in fetal & neonatal medicine·2024
Same author

Ethical and Legal Perspectives on the Treatment of Hypoxic Ischemic Encephalopathy in the Newborn.

Clinics in perinatology·2024
Same author

Pulmonary hypertension in the newborn - Towards precision medicine.

Seminars in fetal & neonatal medicine·2022
Same author

Persistent pulmonary hypertension of the newborn: Historical perspectives.

Seminars in fetal & neonatal medicine·2022
Same author

Medico-legal considerations in the context of neonatal encephalopathy and therapeutic hypothermia.

Seminars in fetal & neonatal medicine·2021
Same author

New Pharmacologic Approaches to Bronchopulmonary Dysplasia.

Journal of experimental pharmacology·2021
Same journal

A Comparative Study of the Effects of Lipid Formulations on Retinopathy of Prematurity.

Current pediatric reviews·2026
Same journal

Uniparental Disomy: A Scoping Review of Diagnostic Challenges, Clinical Spectrum, and Counselling Implications.

Current pediatric reviews·2026
Same journal

Expression and Correlation Analysis of Neuropeptide Family Members in the Peripheral Blood of Patients with COVID-19.

Current pediatric reviews·2026
Same journal

From Etiology to Therapy: A Comprehensive Review of Pediatric Community-acquired Pneumonia.

Current pediatric reviews·2026
Same journal

When the Victim is a Boy: Reframing Sexual Offences Against Male Children in Indian Law.

Current pediatric reviews·2026
Same journal

Expanding the Clinical and Genetic Landscape of UQCRC2-related Mitochondrial Complex III Deficiency: A Case Report and Literature Review.

Current pediatric reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

2.8K

Surfactant-associated proteins: structure, function and clinical implications.

Anastasia K Ketko, Steven M Donn1

  • 18-621 C.S. Mott Children's Hospital, 1540 E. Hospital Drive, Ann Arbor, MI 48109-5254, USA.

Current Pediatric Reviews
|August 5, 2014
PubMed
Summary
This summary is machine-generated.

Surfactant proteins are crucial for lung function and treating respiratory distress syndrome. Understanding these proteins drives advancements in synthetic therapies for lung diseases.

More Related Videos

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

2.2K
An Experimental System to Study Mechanotransduction in Fetal Lung Cells
09:35

An Experimental System to Study Mechanotransduction in Fetal Lung Cells

Published on: February 16, 2012

12.6K

Related Experiment Videos

Last Updated: Apr 26, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

2.8K
Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

2.2K
An Experimental System to Study Mechanotransduction in Fetal Lung Cells
09:35

An Experimental System to Study Mechanotransduction in Fetal Lung Cells

Published on: February 16, 2012

12.6K

Area of Science:

  • Pulmonary physiology and respiratory medicine.

Background:

  • Surfactant replacement therapy is standard for infant respiratory distress syndrome.
  • Surfactant-associated proteins are essential for pulmonary surfactant structure and function.
  • Deficiencies in surfactant proteins lead to significant lung pathology.

Purpose of the Study:

  • To review current knowledge of surfactant proteins.
  • To highlight the importance of this knowledge for future therapeutic advancements.

Main Methods:

  • Literature review of surfactant protein research.
  • Analysis of structural and functional diversity of surfactant proteins.

Main Results:

  • Surfactant proteins play complex roles in normal pulmonary physiology.
  • Engineering synthetic surfactant protein constructs is a key research area.

Conclusions:

  • Understanding surfactant proteins is pivotal for treating respiratory distress syndrome.
  • This knowledge is essential for developing therapies for other surfactant deficiency lung diseases.