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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Apr 26, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

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Innovative agents in multiple myeloma.

Beth Faiman1, Tiffany Richards1

  • 1Cleveland Clinic Foundation, Cleveland, Ohio, and University of Texas MD Anderson Cancer Center, Houston, Texas.

Journal of the Advanced Practitioner in Oncology
|August 5, 2014
PubMed
Summary

Newer targeted therapies are improving survival for multiple myeloma (MM) patients. Understanding these advanced treatments and clinical trials is crucial for managing this incurable bone marrow cancer.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma (MM) is an incurable plasma cell cancer.
  • Recent advances in understanding MM pathogenesis have led to improved patient survival.
  • Newer therapeutic agents are transforming MM treatment paradigms.

Purpose of the Study:

  • To review novel targeted agents for relapsed/refractory multiple myeloma.
  • To highlight the importance of understanding the evolving drug landscape for MM.
  • To emphasize the role of clinical trials in accessing innovative therapies.

Main Methods:

  • Review of current literature on novel MM agents.
  • Discussion of immunomodulatory drugs and proteasome inhibitors.
  • Exploration of targeted therapies with unique mechanisms of action.

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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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Related Experiment Videos

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Main Results:

  • Significant survival improvements in MM patients over the past decade.
  • Emergence of novel drug classes including immunomodulatory drugs and proteasome inhibitors.
  • Ongoing investigation of targeted drugs with sophisticated mechanisms.

Conclusions:

  • Improved understanding of MM genetics aids risk stratification and personalized treatment.
  • Nurses and advanced practitioners must stay informed about new MM therapies.
  • Awareness of clinical trials is vital for patient access and therapeutic benefit assessment.