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Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy
Jisu Kim1, Ching-Hsuan Tung, Yongdoo Choi
1Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea. ydchoi@ncc.re.kr.
Chemical Communications (Cambridge, England)
|August 5, 2014
Abstract:
A smart dual-targeted theranostic agent becomes highly fluorescent and phototoxic only when its linker is cleaved by tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
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