Formulation of diclofenac for dermal delivery

Area of Science:

• Pharmacology
• Dermatology
• Drug Delivery

Background:

• Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) synthesized in the 1960s.
• Available in various forms, including ophthalmic, oral, parenteral, rectal, and topical preparations.
• Primary indications include pain and inflammation management, with use in treating actinic keratosis.

Purpose of the Study:

• To review DF pharmacokinetics and metabolism after oral and topical administration.
• To critically examine formulation approaches for enhanced dermal delivery of DF.
• To identify novel formulation strategies for improved DF skin penetration.

Main Methods:

• Literature review of pharmacokinetic and metabolism studies.
• Analysis of various formulation strategies for topical DF.
• Exploration of new approaches for enhancing dermal penetration.

Main Results:

• Overview of DF absorption, distribution, metabolism, and excretion following different administration routes.
• Evaluation of existing topical formulations and their efficacy in enhancing DF delivery.
• Identification of promising new formulation technologies for improved skin penetration.

Conclusions:

• Topical DF offers a viable route for managing localized pain and inflammation.
• Formulation science plays a critical role in optimizing DF's dermal delivery and therapeutic outcomes.
• Further research into novel formulations is essential for maximizing the potential of topical DF.