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Updated: Apr 26, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Insights into EPR effect versus lectin-mediated targeted delivery: biodegradable polycarbonate micellar nanoparticles
Amalina Binte Ebrahim Attia1, Pamela Oh, Chuan Yang
1Institute of Bioengineering and Nanotechnology (IBN), 31 Biopolis Way, The Nanos, #04-10, 138669, Singapore.
Abstract:
Polymeric micelles with and without galactose are synthesized to study liver targeting ability in an orthotopic HCC rat model. Micelles with galactose accumulate more in the healthy liver tissue instead of HCC, while micelles without galactose amass in HCC by the EPR effect. These micelles show great potential as drug delivery carriers to target either the liver or HCC.
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