Related Experiment Video
Updated: Apr 26, 2026
Postoperative Ileus Murine Model
Published on: July 12, 2024
Validation of an acoustic gastrointestinal surveillance biosensor for postoperative ileus
Brennan M R Spiegel1, Marc Kaneshiro, Marcia M Russell
1Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, USA, bspiegel@mednet.ucla.edu.
Insights
A new acoustic gastro-intestinal surveillance (AGIS) biosensor accurately distinguishes postoperative ileus (POI) patients from healthy individuals. This non-invasive device shows promise for guiding feeding decisions after abdominal surgery.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Biomedical Engineering
Background:
- Postoperative ileus (POI) complicates recovery, increasing costs and hospital stays.
- Objective markers are needed to guide feeding protocols for surgical patients.
- A novel acoustic gastro-intestinal surveillance (AGIS) biosensor was developed.
Purpose of the Study:
- To evaluate the efficacy of the AGIS biosensor in differentiating healthy individuals from postoperative patients.
- To assess the AGIS biosensor's ability to distinguish between patients who tolerate feeding and those with POI.
Main Methods:
- The AGIS biosensor, a disposable device with a microphone, was adhered to the abdominal wall.
- Intestinal acoustic event rates were recorded in healthy controls and two postoperative groups: those tolerating feeding and those with POI.
- Statistical analysis (ANOVA, t-tests) compared acoustic rates among the groups.
Main Results:
- Mean intestinal rates were significantly different across healthy controls (0.14 events/sec), fed patients (0.03 events/sec), and POI patients (0.016 events/sec) (ANOVA p < 0.001).
- AGIS achieved 100% sensitivity and 97% specificity in distinguishing postoperative patients from controls.
- Acoustic rates were significantly higher in fed patients compared to POI patients (p = 0.017).
Conclusions:
- Non-invasive acoustic monitoring using AGIS effectively differentiates between POI and non-POI subjects.
- Further research is warranted to explore AGIS for predicting POI risk and optimizing postoperative feeding strategies.
Background:
Postoperative ileus (POI) can worsen outcomes, increase cost, and prolong hospitalization. An objective marker could help identify POI patients who should not be prematurely fed. We developed a disposable, non-invasive acoustic gastro-intestinal surveillance (AGIS) biosensor. We tested whether AGIS can distinguish healthy controls from patients recovering from abdominal surgery.
Study Design:
AGIS is a disposable plastic device embedded with a microphone that adheres to the abdominal wall and connects to a computer that measures acoustic event rates. We compared intestinal rates of healthy subjects using AGIS for 60 min after a standardized meal to recordings of two postoperative groups: (1) patients tolerating standardized feeding and (2) POI patients. We compared intestinal rates among groups using ANOVA and t tests.
Results:
There were 8 healthy controls, 7 patients tolerating feeding, and 25 with POI; mean intestinal rates were 0.14, 0.03, and 0.016 events per second, respectively (ANOVA p < 0.001). AGIS separated patients from controls with 100 % sensitivity and 97 % specificity. Among patients, rates were higher in fed versus POI subjects (p = 0.017).
Conclusion:
Non-invasive, abdominal acoustic monitoring distinguishes POI from non-POI subjects. Future research will test whether AGIS can identify patients at risk for development of POI and assist with postoperative feeding decisions.
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