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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
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Chronic thromboembolic pulmonary hypertension: evolution in management
Barbara L LeVarge1, Richard N Channick
1aDepartment of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center bDepartment of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Current Opinion in Pulmonary Medicine
|August 6, 2014
Summary
Surgery is the primary treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). Medical therapies, like riociguat, are increasingly used for inoperable or post-surgery CTEPH patients.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Vascular Surgery
Background:
- Chronic thromboembolic pulmonary hypertension (CTEPH) is a significant cause of pulmonary hypertension.
- While surgery offers a potential cure, some patients have inoperable disease, necessitating alternative treatments.
- Pulmonary arterial hypertension (PAH) therapies are increasingly utilized in these specific CTEPH cases.
Purpose of the Study:
- To review the current management strategies for CTEPH.
- To highlight the role of medical therapies in operable and inoperable CTEPH.
- To discuss the evidence supporting riociguat in CTEPH management.
Main Methods:
- Review of recent clinical trials and evidence in CTEPH management.
- Analysis of surgical outcomes and medical therapy efficacy.
- Focus on randomized controlled trials, including riociguat's impact.
Main Results:
- Surgical thromboendarterectomy is the preferred treatment for operable CTEPH, with good outcomes.
- Medical management is gaining importance for inoperable, recurrent, or persistent CTEPH.
- Riociguat demonstrated significant improvements in exercise capacity, functional class, and hemodynamics in a large CTEPH trial.
Conclusions:
- Surgical management remains the standard for operable CTEPH.
- Medical therapy, particularly riociguat, is a valuable option for inoperable CTEPH or post-surgical cases.
- Further research into angioplasty for CTEPH is ongoing.
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