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Updated: Apr 26, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Synthesis of functionalized arylaziridines as potential antimicrobial agents
Arianna Giovine1, Marilena Muraglia2, Marco Antonio Florio3
1Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. giovinearianna@gmail.com.
Abstract:
By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
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