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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Macro-and microelements imbalance in etiology and progression of bronchial asthma in children]
Insights
Asthma severity in children correlates with blood serum element levels. Uncontrolled asthma shows reduced magnesium and zinc, with excess copper and calcium, impacting immune function and disease severity.
Area of Science:
- Pediatric Pulmonology
- Clinical Chemistry
- Environmental Health
Context:
- Asthma is a chronic respiratory disease affecting children worldwide.
- Disease severity is linked to various physiological changes, including potential alterations in essential element levels.
- Understanding these elemental imbalances can offer insights into disease mechanisms and management.
Purpose:
- To investigate the relationship between asthma severity in children and the concentration of macro- and microelements in their blood serum.
- To identify specific elemental profiles associated with different levels of asthma control.
Summary:
- This study analyzed serum macro- and microelement levels in 107 children (aged 10-18) with asthma, categorized by control level (controlled, partly controlled, uncontrolled).
- Atomic absorption spectrophotometry revealed reduced magnesium and zinc, and elevated copper and calcium levels in children with poorer asthma control.
- Uncontrolled asthma was associated with more pronounced elemental imbalances, linked to hypoxia, energy deficits, bronchial hyperreactivity, and immune dysfunction.
Impact:
- Findings highlight the role of elemental dysregulation in asthma severity and immune system compromise.
- Suggests that identifying and correcting these elemental imbalances may be crucial for comprehensive asthma management in children.
- Emphasizes the need for differential diagnosis and tailored treatments considering these biochemical alterations.
Abstract:
The aim of our work was the study of macro-and microelemensts characteristics of the state of the blood serum of children with asthma, depending on the severity. A total of 107 children aged 10 to 18 years with asthma in the acute stage. The results of the proposed asthma control test (GINA, 2011) to the level of asthma control the children were distributed as follows: 34 (31.8%)--with controlled, 47 (43.9%)--partly controlled and 26--with uncontrolled bronchial asthma. Investigation of serum trace elements were determined by atomic absobtsionnoy spectrophotometry. Found that with varying degrees of control of asthma changes were reduction of magnesium, zinc, when excessive amounts of copper and calcium. We show some dizelements in patients with nontrol bronhial asthma. The most pronounced manifestation dyzelements documented in patients with uncontrolled asthma. It is with same with uncontrolled asthma, there are marked hypoxic change, energy shortage, bronchial hyperreactivity, as a result of increasing stress level of response to an antigen, reduce antioxidant enzyme systems, immune system dysfunction. This changes in the macro-and microelement composition of the blood significantly reduce the reserves of the immune system, chronic inflammatory processes in the bronches, which exacerbates the severity of the disease, which in practice requires a differential diagnosis, comprehensive treatment based on identified dyzelements states.
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