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Updated: Apr 8, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Insights
Children with bronchial asthma show increased acrocentric chromosome associations and reduced lymphocyte mitotic activity. These cytogenetic changes may indicate a higher risk or severity in pediatric asthma patients.
Area of Science:
- Cytogenetics
- Pediatric Pulmonology
- Immunology
Context:
- Bronchial asthma is a common chronic respiratory disease in children.
- Cytogenetic analysis can reveal cellular abnormalities.
- Lymphocyte chromosomes offer insights into genetic and cellular health.
Purpose:
- To investigate the cytogenetic characteristics of children with bronchial asthma.
- To analyze the association of acrocentric chromosomes in pediatric asthma patients.
- To evaluate mitotic activity in lymphocytes of children with asthma.
Summary:
- This study analyzed prometaphase chromosomes in lymphocytes of 82 children (6-18 years) with bronchial asthma.
- Increased frequency of acrocentric chromosome associations (D-D, G-G, D-G) was observed in children with uncontrolled asthma.
- Lower mitotic activity was noted in asthmatic children compared to healthy controls, correlating with disease activity.
Impact:
- Findings suggest potential cytogenetic markers for bronchial asthma in children.
- Highlights a link between chromosome abnormalities and asthma severity.
- May inform future diagnostic or therapeutic strategies for pediatric asthma.
Abstract:
The learning of cytyogenetic special of cariotip in children with the bronchial asthma maked by course of the investigation of prometahyases chromosomes of limphocytes of the periferic bloods. The quantity of association of acrocentric chromosome was analised. The 82 children in age 6-18 years old with the bronchial asthma and with the different control were learned by results of asthma--test control. In children with the noncontrol bronchial asthma the big frequency of of association of acrocentric chromosome 13-15 (D-D), 21-22 (G-G) n 13-15--21-22 (D-G) were received. In patients with the bronchial asthma the lover mitotic activity by healthy were marked (P(N) < 0.05). With the degree of activity it was decreased.
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