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Myofibroblasts in peripheral giant cell granuloma. Light and electron microscopic study
1Section of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
International Journal of Oral and Maxillofacial Surgery
|October 1, 1989
Summary
Myofibroblasts, cells involved in tissue repair, were identified in peripheral giant cell granuloma (PGCG). This finding suggests PGCG is a reactive condition, not a neoplastic one.
Area of Science:
- Oral pathology
- Surgical pathology
- Histopathology
Background:
- Myofibroblasts are implicated in various pathological conditions.
- Giant cell-containing lesions, such as central giant cell granuloma and tendon sheath tumors, often feature myofibroblasts.
Purpose of the Study:
- To investigate the presence and characteristics of myofibroblasts in peripheral giant cell granuloma (PGCG).
- To determine if myofibroblasts contribute to the nature of PGCG.
Main Methods:
- Histochemical analysis using the TP-Levanol fast cyanine 5RN procedure.
- Electron microscopy for cellular examination.
Main Results:
- Myofibroblasts were identified in peripheral giant cell granuloma (PGCG).
- Some myofibroblasts within PGCG exhibited intracellular collagen fibrils.
Conclusions:
- The presence of myofibroblasts in PGCG supports its classification as a reactive lesion.
- These findings contribute to understanding the cellular composition and pathogenesis of PGCG.