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Related Concept Videos

Echo01:06

Echo

859
The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case,...
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Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

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The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
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Related Experiment Video

Updated: Jan 10, 2026

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

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Threshold-distance functions predict speech recognition with cochlear implants.

E Kludt1, S Ewald2, N Prenzler2

  • 1Clinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany. kludt.eugen@mh-hannover.de.

Scientific Reports
|November 29, 2025
PubMed
Summary
This summary is machine-generated.

Cochlear implant electrode distance from the modiolus significantly impacts electrically-evoked compound action potential (eCAP) thresholds. This distance-threshold relationship may predict speech understanding outcomes in cochlear implant users.

Keywords:
Auditory nerve degenerationCochlear healthCompound action potentialsNeuronal survivalPull-back technique

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Area of Science:

  • Neurosurgery
  • Audiology
  • Biomedical Engineering

Background:

  • Cochlear implantation outcomes vary due to factors like auditory nerve degeneration.
  • Assessing the auditory nerve's functional state is crucial for optimizing cochlear implant performance.

Purpose of the Study:

  • To investigate the relationship between electrode-modiolus distance and electrically-evoked compound action potentials (eCAPs).
  • To determine if the slope of the eCAP threshold-distance function can predict speech understanding variability.

Main Methods:

  • Monopolar stimulation was used in human subjects with cochlear implants.
  • Electrode-modiolus distance was quantified using fluoroscopy and cone-beam computed tomography.
  • eCAP thresholds were measured and correlated with electrode position.

Main Results:

  • Electrode-modiolus distance explained up to 91% of the variability in eCAP thresholds.
  • A linear relationship was observed between eCAP threshold and distance from the modiolus for individual electrodes.
  • The slope of this relationship explained up to 67% of the variability in speech understanding.

Conclusions:

  • The slope of the eCAP threshold-distance function is a potential marker for the functional state of spiral ganglion cells.
  • This metric may aid in assessing individual patient status and optimizing cochlear implant rehabilitation.