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Updated: Apr 26, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Adverse effects to transfusion with red donor blood cells are frequent]
Hans-Christian Pommergaard1, Astrid Nørgaard, Jakob Burcharth
1Gastroenheden, Kirurgisk Sektion, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. hcpommergaard@gmail.com.
Abstract:
Adverse effects to transfusion with red donor blood cells are potentially life-threatening. Due to screening, transmission of infectious diseases has decreased; however, the risk is still present. Various immune reactions are common including simple allergic reactions as well as devastating conditions such as transfusion-related acute lung injury and circulatory overload in patients with heart disease. Knowledge of the clinical signs of transfusion-related complications is important for clinicians in order to provide the best possible treatment.
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