Bone health in cerebral palsy: who's at risk and what to do about it?

Christine Murray Houlihan1

  • 1Eastern Virginia Medical School, 601 Children's Lane, Norfolk, VA 23507, USA. Tel: +1 757 668 7473; Fax: + 757 668 7474;

Insights

Children with cerebral palsy (CP) often have low bone mass, increasing fracture risk. This review covers diagnosis, risk factors, and management strategies for low bone density in pediatric CP patients.

Area of Science:

  • Pediatrics
  • Orthopedics
  • Bone Metabolism

Background:

  • Cerebral palsy (CP) is the most common childhood condition linked to low bone mass.
  • Children with CP experience decreased bone density, leading to fragility fractures that negatively impact function and quality of life.
  • Addressing low bone mass is crucial for preventing lifelong fracture risks.

Purpose of the Study:

  • To review the diagnosis of low bone mass in children with CP.
  • To identify risk factors contributing to low bone density in this population.
  • To explore prevention and treatment strategies for low bone mass in children with CP.

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on bone health in pediatric CP.
  • The review covers diagnostic approaches, risk factors, and therapeutic interventions.

Main Results:

  • Low bone mass is a significant issue in children with CP, elevating fracture risk.
  • Accurate fracture risk prediction, prevention, and treatment are vital for improving outcomes.
  • Maximizing bone accrual during growth is essential for long-term bone health.

Conclusions:

  • Early diagnosis and intervention for low bone mass are critical in children with CP.
  • Comprehensive management strategies are needed to mitigate fracture risk and improve quality of life.
  • Further research into optimizing bone health in pediatric CP is warranted.

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
17
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K