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Updated: Apr 26, 2026
Murine Model of Wound Healing
Published on: May 28, 2013
Topical vitamin K1 promotes repair of full thickness wound in rat
Ali Asghar Hemmati1, Gholamreza Houshmand2, Behnam Ghorbanzadeh3
1Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ; Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Objectives:
Application of vitamin K to the skin has been used for suppression of pigmentation and resolution of bruising. However, in rats, no study was reported on its effect regarding wound healing. Thus, the present study was designed to examine the healing effects of creams prepared from vitamin K1 on full-thickness wound in rats.
Materials And Methods:
For inducing full-thickness wound in rats, the excisional wound model was used. Five groups consisting of 8 rats each were used. Vitamin K cream (1% and 2%, w/w) was prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing was defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination was also done.
Results:
The effects produced by the topical vitamin K showed significant (P < 0.01) healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength. Histopathological studies also showed improvement with vitamin K.
Conclusions:
Topical vitamin K demonstrates wound healing potential in full-thickness wound model.
