Correlation between glycated haemoglobin levels and random blood glucose
Journal of Ayub Medical College, Abbottabad : JAMC
|August 8, 2014
Summary
Glycated haemoglobin (HbA1c) testing correlates positively with random blood glucose levels in diabetic patients. This finding supports HbA1c as a reliable indicator of average blood glucose control over time.
Area of Science:
- Clinical Chemistry
- Endocrinology
- Diabetes Mellitus Research
Background:
- Glycated haemoglobin (HbA1c) reflects average plasma glucose over 120 days.
- HbA1c is crucial for monitoring long-term glycemic control in diabetes.
- Understanding the correlation between HbA1c and random glucose is vital for patient management.
Purpose of the Study:
- To investigate the correlation between HbA1c levels and random blood glucose measurements.
- To assess the reliability of random glucose as an indicator of glycemic control in relation to HbA1c.
Main Methods:
- Descriptive study of 106 diabetic outpatients.
- Measurement of random blood glucose and HbA1c using venous blood samples.
- BIO-RAD D-10 HPLC Method for HbA1c analysis and Pearson's correlation for statistical analysis.
Main Results:
- A significant linear positive correlation was identified between HbA1c levels and random blood glucose levels.
- Data visualization using scatter plots supported the observed correlation.
- A p-value < 0.01 indicated statistical significance.
Conclusions:
- A significant positive linear relationship exists between HbA1c and random blood glucose.
- HbA1c is a valuable marker for assessing long-term glycemic control in diabetic individuals.
More Related Videos
Related Concept Videos
Hyperglycemia
23
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
23
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
11
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
11
Diabetes Mellitus: Type 2 and Gestational
4.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.8K
Hypoglycemia and Glucagon
1.3K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Hypoglycemia
22
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
22
Hormones Regulating Blood Glucose
7.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
7.4K


