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Vascular Reactivity is Impaired and Associated With Walking Ability in Patients With Intermittent Claudication

Rita de Cassia Gengo E Silva1, Nelson Wolosker2, Juan Carlos Yugar-Toledo3

  • 1Medical Surgical Department, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil rita.gengo@usp.br.

Angiology
|August 8, 2014
PubMed

Insights

Vascular reactivity and walking ability are impaired in patients with intermittent claudication (IC) and peripheral artery disease (PAD). Impaired vascular function correlates with PAD severity and reduced walking capacity.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Exercise Physiology

Background:

  • Intermittent claudication (IC) is a common symptom of peripheral artery disease (PAD).
  • Impaired vascular reactivity is a hallmark of endothelial dysfunction.
  • The relationship between vascular function, walking impairment, and PAD severity requires further elucidation.

Purpose of the Study:

  • To assess vascular reactivity in patients with IC.
  • To investigate the association between vascular reactivity, walking ability, and PAD severity.

Main Methods:

  • Vascular reactivity assessed via flow-mediated dilation (FMD) and nitroglycerin-induced vasodilation (NID) in the brachial artery.
  • Walking ability measured using the 6-minute walk test.
  • Study included 63 patients with IC and 17 healthy controls.

Main Results:

  • Patients with IC exhibited significantly worse vascular reactivity and walking ability compared to controls.
  • Ankle-brachial index correlated with FMD, NID, and walking distances.
  • Nitroglycerin-induced vasodilation and walking ability decreased with increasing PAD severity.

Conclusions:

  • Vascular reactivity is impaired in patients with intermittent claudication.
  • Impaired vascular function is associated with peripheral artery disease severity and reduced walking ability.

Keywords:
endotheliumintermittent claudicationmuscleperipheral arterial diseasesmoothvascularvasodilationwalking

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