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Related Experiment Videos

Universal prenatal hepatitis B testing: is it cost-effective?

R L Koretz1

  • 1Division of Gastroenterology, Olive View Medical Center, Sylmar, California.

Obstetrics and Gynecology
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

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Universal prenatal screening for hepatitis B is a costly strategy. The expense to prevent a single case in infants born to mothers without risk factors is significantly higher than for those with risk factors, questioning its cost-effectiveness.

Area of Science:

  • Hepatology
  • Public Health
  • Maternal-Fetal Medicine

Background:

  • Universal prenatal screening for hepatitis B is a recent policy change.
  • Previous policy focused on screening individuals with known risk factors.
  • The new policy aims to prevent perinatal hepatitis B transmission.

Purpose of the Study:

  • To evaluate the cost-effectiveness of universal prenatal hepatitis B screening.
  • To analyze the challenges associated with screening the general pregnant population.
  • To compare the costs of preventing hepatitis B in neonates with and without maternal risk factors.

Main Methods:

  • Analysis of current screening policies and their costs.
  • Evaluation of hepatitis B transmission rates in different maternal risk groups.

Related Experiment Videos

  • Cost-effectiveness analysis comparing universal screening versus risk-factor-based screening.

    • Main Results:

    • Universal screening is significantly more expensive than risk-factor-based screening.
    • The cost to prevent one case of hepatitis B in neonates of mothers without risk factors is $180,000.
    • This cost is 15 times higher than preventing cases in neonates of mothers with risk factors.
    • Several factors complicate screening, including low positivity rates and prophylaxis efficacy in hepatitis B e antigen-negative pregnancies.

    Conclusions:

    • Universal prenatal hepatitis B screening in the general population is not cost-effective.
    • Targeted screening based on risk factors remains a more economical approach.
    • Further research may be needed to optimize strategies for preventing perinatal hepatitis B transmission.