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Mal de meleda - through history and today.
1Ana Bakija-Konsuo, MD, PhD, "Cutis" Clinic for Dermatovenereology, Vukovarska 22, 20000 Dubrovnik, Croatia; ana.bakija-konsuo@du.t-com.hr.
Acta Dermatovenerologica Croatica : ADC
|August 9, 2014
Summary
Meleda disease, a hereditary palmoplantar keratoderma, is caused by mutations in the SLURP1 gene. This review traces its history and recent genetic discoveries.
Area of Science:
- Dermatology
- Medical Genetics
Background:
- Meleda disease is a rare, inherited palmoplantar keratoderma.
- First described in 1826 on Mljet Island, Croatia.
Observation:
- This article provides a historical review of Meleda disease literature.
- Recent research has identified the genetic basis of the condition.
Findings:
- The gene responsible for Meleda disease is located on chromosome 8qter.
- Mutations in the secreted LY6/PLAUR-related protein1 (SLURP1) gene cause the disease.
Implications:
- Understanding the genetic cause aids in diagnosis and potential therapeutic strategies.
- Preserves the historical and scientific recognition of 'Mal de Meleda'.
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