[Organ and function preservation in prostate cancer].

Area of Science:

• Oncology
• Urology
• Cancer Research

Context:

• Prostate cancer treatments carry risks impacting quality of life.
• Overdiagnosis of non-life-threatening prostate tumors leads to overtreatment.
• Current efforts focus on reducing overtreatment and its associated risks.

Purpose:

• To evaluate the current landscape of prostate cancer treatment options beyond traditional curative approaches.
• To assess the efficacy and safety of emerging prostate-sparing and deferred treatment strategies.
• To highlight the limitations in available data for novel prostate cancer interventions.

Summary:

• Curative prostate cancer treatments pose risks to quality of life.
• Several prostate-sparing or deferred treatment options are under investigation.
• Insufficient efficacy and safety data exist for many of these experimental approaches, including focal ablation and active surveillance.
• Active surveillance may be suitable for select patients with favorable risk profiles and high competing mortality risk.

Impact:

• Highlights the experimental nature of many novel prostate cancer treatments.
• Emphasizes the need for more long-term data to validate new therapeutic strategies.
• Informs clinical decision-making regarding prostate cancer management, particularly for elderly patients or those with comorbidities.