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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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The implication of periodontitis in vascular endothelial dysfunction
1Department of Periodontics, Tatyasaheb Kore Dental College & Research Centre, Kolhapur, India.
European Journal of Clinical Investigation
|August 9, 2014
Summary
Periodontitis, a common gum infection, can lead to systemic inflammation and endothelial dysfunction. Periodontal therapy may improve vascular health by reducing inflammation and improving endothelial function.
Area of Science:
- Oral Health
- Cardiovascular Health
- Inflammation
Background:
- Periodontitis is a prevalent oral infection causing tooth loss.
- Periodontal infections involve gram-positive and gram-negative bacteria.
- Periodontal pathogens can induce systemic inflammation via the bloodstream.
Purpose of the Study:
- To review the pathophysiology of endothelial dysfunction linked to periodontal infection.
- To highlight the association between periodontitis and endothelial dysfunction.
- To examine the impact of periodontal treatment on endothelial function.
Main Methods:
- Systematic review of studies on periodontitis and vascular endothelial function.
- Searched MEDLINE database (1989-2012) using keywords: 'Periodontitis', 'vascular endothelium', 'endothelial dysfunction', 'periodontal bacteria', 'periodontal therapy'.
- Included human and animal models; screened systematic reviews and meta-analyses; considered English-language studies.
Main Results:
- Chronic periodontitis alters vascular response.
- Increased expression of pro-inflammatory cytokines and adhesion molecules observed.
- These factors contribute to vascular endothelial dysfunction.
Conclusions:
- Periodontal infection is linked to endothelial dysfunction.
- Periodontal therapy shows potential to improve vascular endothelial function.
- Addressing periodontitis may mitigate systemic vascular complications.
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