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Updated: Apr 26, 2026
Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
Yanmei Jiao1, Xin Sun1, Xiaojie Huang1
1Center for Infectious Diseases, Beijing You-an Hospital, Capital Medical University, Beijing 100069, China.
Abstract:
The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group.
