Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

22.0K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
22.0K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

18.1K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
18.1K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.5K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.5K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

4.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.4K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

16.6K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
16.6K
Capillary Exchange01:28

Capillary Exchange

10.7K
The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
10.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidelines for evaluating endothelial function in vascular tissue.

American journal of physiology. Heart and circulatory physiology·2026
Same author

From blood vessels to lymphatics and back again.

Function (Oxford, England)·2025
Same author

Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)-Hemorrhagic Shock and Resuscitation (HSR)-Induced Microvascular Leakage.

Microcirculation (New York, N.Y. : 1994)·2025
Same author

Leading the Understanding of Lymphatic Function.

Function (Oxford, England)·2025
Same author

Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles.

Life sciences·2023
Same journal

Association between retinal microcirculation and cardiac function: A cross-sectional study using OCTA.

Microvascular research·2026
Same journal

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

Microvascular research·2026
Same journal

Association of circulating biomarkers of glycocalyx injury, sirtuin 1, and NFκB p65 in individuals with type 2 diabetes and concurrent arterial hypertension.

Microvascular research·2026
Same journal

Targeting miR-10 alleviates atherosclerosis by enhancing intestinal ABCA1-mediated cholesterol efflux and repairing intestinal barrier.

Microvascular research·2026
Same journal

The effect of acute high-intensity interval exercise on microvascular function and local skeletal muscle oxygenation.

Microvascular research·2026
Same journal

RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.

Microvascular research·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.7K

Mechanical forces and lymphatic transport.

Jerome W Breslin1

  • 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Microvascular Research
|August 10, 2014
PubMed
Summary
This summary is machine-generated.

This review explores how lymphatic vessels optimize lymph flow using mechanical forces. Understanding these mechanisms is crucial for treating lymphatic insufficiency and lymphedema.

Keywords:
Lymphatic contractile cycleLymphatic endotheliumLymphatic muscleLymphatic myogenic responseLymphedema

More Related Videos

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.0K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.9K

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.7K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.0K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.9K

Area of Science:

  • Physiology
  • Vascular Biology
  • Biomechanics

Background:

  • Lymphatic vessels form a complex network crucial for fluid balance and immune surveillance.
  • Lymph flow is regulated by intrinsic pumping of lymphangions and external mechanical forces.
  • Dysfunctional lymphatic systems lead to conditions like lymphedema.

Purpose of the Study:

  • To review the current understanding of lymphatic vessel function in response to mechanical forces.
  • To discuss recent advancements in lymphatic endothelial cell and smooth muscle mechanisms.
  • To highlight the importance of mechanosensation for lymphatic health.

Main Methods:

  • Literature review of recent developments in lymphatic physiology.
  • Analysis of studies on lymphangion pump function and valve mechanisms.
  • Examination of molecular mechanisms in lymphatic endothelial cells.

Main Results:

  • Lymphatic endothelial cells play an active role in lymph formation.
  • Inflow/outflow pressures and shear stress significantly impact lymphangion pump function.
  • Lymphatic valves and collecting lymphatic permeability are key regulatory points.
  • Molecular mechanisms underlying lymphatic vessel mechanosensation are being elucidated.

Conclusions:

  • Optimizing lymph flow involves intricate responses to mechanical stimuli.
  • Understanding these physiological mechanisms is vital for lymphedema pathogenesis and treatment.
  • Further research into lymphatic vessel mechanobiology holds therapeutic potential.