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Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
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Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

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Plasma indoxyl sulfate and estimated glomerular filtration rate

Daiji Yoshikawa1, Hideki Ishii, Susumu Suzuki

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine.

Circulation Journal : Official Journal of the Japanese Circulation Society
|August 12, 2014
PubMed

Insights

High indoxyl sulfate (IS) levels predict major adverse cardiac events (MACE) in patients with coronary artery disease. This risk is particularly pronounced in individuals with moderate kidney dysfunction (eGFR 59-30 ml·min(-1)·1.73 m(-2)).

Area of Science:

  • Cardiology
  • Nephrology
  • Toxicology

Background:

  • Indoxyl sulfate (IS) is a uremic toxin associated with cardiovascular and systemic toxicity.
  • The prognostic significance of blood IS levels for long-term outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of plasma indoxyl sulfate (IS) levels for major adverse cardiac events (MACE) in patients with coronary artery disease (CAD).

Main Methods:

  • A cohort of 311 patients with CAD were followed for a median of 759 days.
  • Plasma IS levels and estimated glomerular filtration rate (eGFR) were measured.
  • The primary endpoint was the occurrence of MACE.

Main Results:

  • Patients with MACE had significantly higher plasma IS levels compared to those without (P<0.001).
  • Kaplan-Meier analysis revealed a significantly lower MACE-free rate in the highest IS quartile (Q4) (P<0.001).
  • In patients with eGFR 59-30 ml·min(-1)·1.73 m(-2), the highest IS quartile was associated with a significantly lower MACE-free rate (P=0.015).

Conclusions:

  • Plasma IS level is a significant predictor of MACE in patients with CAD.
  • This association is particularly strong in patients with moderate kidney dysfunction (eGFR 59-30 ml·min(-1)·1.73 m(-2)).
Abstract

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