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Updated: Apr 26, 2026

Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
Signalling functions of coenzyme A and its derivatives in mammalian cells
Hongorzul Davaapil1, Yugo Tsuchiya1, Ivan Gout1
1*Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Abstract:
In all living organisms, CoA (coenzyme A) is synthesized in a highly conserved process that requires pantothenic acid (vitamin B5), cysteine and ATP. CoA is uniquely designed to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. The role of CoA and its thioester derivatives, including acetyl-CoA, malonyl-CoA and HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), in the regulation of cellular metabolism has been extensively studied and documented. The main purpose of the present review is to summarize current knowledge on extracellular and intracellular signalling functions of CoA/CoA thioesters and to speculate on future developments in this area of research.
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