Related Experiment Video
Updated: Jan 29, 2026
08:51
Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
8.9K
Coenzyme A in Brain Biology and Neurodegeneration
Dejun Zhang1, Charlie Brett1, Jason Cho1
1Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.
Biomedicines
|January 28, 2026
Summary
Coenzyme A (CoA) is vital for neuronal function, and its deficiency causes neurodegeneration. Novel insights into CoA
Area of Science:
- Biochemistry
- Neuroscience
- Metabolic pathways
Background:
- Coenzyme A (CoA) is crucial for cellular metabolism and signaling.
- Disruptions in CoA biosynthesis are linked to neurodegenerative diseases.
- The exact mechanisms connecting CoA deficiency to neuronal dysfunction are not fully understood.
Purpose of the Study:
- To review the established roles of CoA in neuronal metabolism.
- To summarize recent findings on CoA's function in stress responses.
- To explore CoA's antioxidant role via protein CoAlation.
Main Methods:
- Literature review of CoA biology in health and disease.
- Analysis of recent studies on CoA metabolism and redox homeostasis.
- Discussion of novel analytical tools for CoAlation/deCoAlation.
Main Results:
- CoA is essential for neuronal viability, with mutations causing neurodegeneration.
- Disrupted metabolism and redox homeostasis are implicated in CoA deficiency-related neurodegeneration.
- Protein CoAlation represents a novel antioxidant mechanism.
Conclusions:
- CoA plays a critical role in neuronal health and adaptation to stress.
- Understanding the CoAlation/deCoAlation cycle is key to neurodegenerative disease research.
- New diagnostic and therapeutic strategies may emerge from studying CoA biology.
More Related Videos
Related Concept Videos
01:27Cofactors and Coenzymes
87.3K
Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic ions and coenzymes are non-protein organic molecules. Both of these types of helper molecule can be tightly bound to the enzyme or bound only when the substrate binds.
87.3K
01:24Cofactors and Coenzymes
12.8K
Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via ionic interactions or acid-base reactions. However, amino acids cannot catalyze oxidation-reduction and group transfer reactions and need to be aided by non-protein components called cofactors. Cofactors are also referred to as the chemical teeth of an enzyme.
Cofactors can be metallic ions or organic molecules called coenzymes. These types of helper...
Cofactors can be metallic ions or organic molecules called coenzymes. These types of helper...
12.8K
01:57What is Conservation Biology?
24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
01:29Role of Reduced Coenzymes NADH and FADH₂
16.5K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
16.5K
02:59Biological Effects of Radiation
17.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
02:55Synthetic Biology
5.6K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
5.6K