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Updated: Apr 26, 2026
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000
Eommolbanin Ebrahimi1, Abolfazl Akbarzadeh2,1, Elham Abbasi1
1b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Abstract:
New drug delivery systems delivered the active molecules to the target site in a definite manner to produce the desired effects without disturbing the delicate bio-environment. The Fe3O4 magnetic nanoparticles were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. PLGA-PEG1000 triblock copolymer was synthesized by ring-opening polymerization. The properties of this copolymer were characterized using Fourier transform infrared spectroscopy. In addition, the resulting particles were characterized by X-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX.
