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Updated: Apr 26, 2026

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
Published on: June 9, 2023
A rapid and label-free SERS detection method for biomarkers in clinical biofluids
Kien Voon Kong1, Weng Kee Leong, Zhiyong Lam
1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 138667, Singapore.
Abstract:
A metal carbonyl-functionalized nanostructured substrate can be used in a rapid and simple assay for the detection of A1AT, a potential biomarker for bladder cancer, in clinical urine samples. The assay involves monitoring changes in the carbonyl stretching vibrations of the metal carbonyl via surface-enhanced Raman spectroscopy (SERS). These vibrations lie in the absorption spectral window of 1800-2200 cm(-1), which is free of any spectral interference from biomolecules.

