Ultraviolet Sensing-Guided Biomedical Systems: From Label-Free Imaging to Dosimetry and Therapy Feedback.

Area of Science:

• Biomedical Engineering
• Optical Sensing
• Biophotonics

Background:

• Ultraviolet (UV) light interacts selectively with biological molecules like nucleic acids and proteins.
• UV light is increasingly utilized in biosensing, biomedical signal readout, and dose monitoring.
• Current applications span imaging, diagnostics, and therapeutic interventions.

Purpose of the Study:

• To review recent advancements in UV sensing-guided biomedical systems.
• To emphasize key interconnected research directions: label-free imaging, wearable dosimetry, and sensor-assisted therapy.
• To highlight the role of UV technologies in biosensor-oriented biomedical engineering.

Main Methods:

• Review of recent progress in UV sensing technologies for biomedical applications.
• Focus on label-free imaging (UV-PAM, MUSE), wearable UV dosimetry, and sensor-assisted therapeutic platforms.
• Discussion of biosensing principles, AI integration, and translational challenges.

Main Results:

• UV sensing enables label-free nuclear imaging and rapid histology-like readout.
• Wearable UV dosimeters quantify skin exposure, and therapeutic platforms benefit from sensing and feedback.
• Artificial intelligence aids in image enhancement, dose prediction, and decision support.

Conclusions:

• UV sensing technologies offer significant potential in biosensing and biomedical engineering.
• Key challenges include standardization, uncertainty quantification, multimodal integration, and feedback-driven design.
• A sensing-centered perspective clarifies the role of UV technologies in advancing biomedical systems.