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Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD

Quan Wang¹, Renzhe Bi², Songhua Zheng²

¹Department of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow G4 0NW, UK.

|August 27, 2025

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This summary is machine-generated.

This study pioneers the use of large-format single-photon avalanche diode (SPAD) cameras for diffuse speckle contrast analysis (DSCA). This advancement significantly improves the accuracy and robustness of blood flow and tissue perfusion measurements.

Area of Science:

Biomedical Optics
Optical Imaging
Physiological Monitoring

Background:

Diffuse speckle contrast analysis (DSCA) is a key optical imaging method for assessing dynamic biological processes like blood flow.
Single-photon avalanche diode (SPAD) cameras offer high sensitivity and temporal resolution, but their use in large-format arrays for DSCA is limited.
Existing DSCA techniques face challenges in capturing rapid physiological changes with high spatiotemporal detail.

Purpose of the Study:

To introduce and validate the use of a large-format SPAD camera for DSCA.
To enhance the accuracy and robustness of speckle contrast measurements for biological applications.
To demonstrate improved spatiotemporal analysis of tissue perfusion and blood flow.

Main Methods:

Keywords:

DSCA SPAD blood flow laser speckle

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Last Updated: Sep 10, 2025

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Development and implementation of a novel DSCA system utilizing a large-format SPAD camera.

Experimental validation using simulations, phantom studies, and in vivo experiments.

Leveraging high temporal resolution and photon-detection efficiency of SPAD arrays for enhanced data acquisition.

Main Results:

Demonstrated significant improvements in the accuracy and robustness of DSCA measurements.
Successfully captured rapid temporal variations in blood flow over a wide field of view.
Validated the system's capability for detailed spatiotemporal analysis of tissue perfusion.

Conclusions:

The integration of large-format SPAD cameras represents a significant advancement for DSCA.
This technology enhances the potential for precise monitoring of cerebral blood flow and functional tissue parameters.
The findings pave the way for future breakthroughs in optical imaging for biomedical research and clinical applications.