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Risks and effectiveness of compounded bioidentical hormone therapy: a case series
Ruth Davis1, Pelin Batur, Holly L Thacker
11 Cleveland Clinic Lerner College of Medicine of Case Western University , Cleveland, Ohio.
Journal of Women'S Health (2002)
|August 12, 2014
Summary
Bioidentical hormone therapy (BHT) lacks sufficient evidence for safety and efficacy. Healthcare providers recommend FDA-approved treatments for menopausal symptom management due to safety concerns with BHT.
Area of Science:
- Gynecology
- Menopause Management
- Hormone Therapy
Background:
- The Women's Health Initiative publication altered menopause management approaches.
- Bioidentical hormone therapy (BHT) has gained media attention for symptom relief.
- Misconceptions regarding BHT risks and benefits are prevalent due to endorsements.
Observation:
- This article reviews evidence comparing BHT to conventional hormone therapy.
- Case studies from midlife women's clinics highlight BHT safety and efficacy concerns.
- Unexplained endometrial cancer cases were observed in healthy BHT users.
Findings:
- Current evidence is insufficient to support BHT's efficacy or safety.
- BHT poses potential safety risks, including links to endometrial cancer.
- Conventional hormone therapy and FDA-approved regimens offer established safety profiles.
Implications:
- Healthcare providers should exercise caution when considering BHT.
- The use of FDA-approved hormone therapy regimens is recommended for menopause management.
- Further research is needed to establish the safety and efficacy of BHT.
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