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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Fungal Group Zygomycota01:29

Fungal Group Zygomycota

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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

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Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
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Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Related Experiment Video

Updated: Apr 25, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
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Disseminated botryomycosis: a rare presentation.

Benjamin Bashline, Megan Morrison, James Ramirez

    Journal of Drugs in Dermatology : JDD
    |August 14, 2014
    PubMed
    Summary

    Botryomycosis is a rare bacterial skin infection. This case highlights disseminated botryomycosis in an elderly female, presenting a diagnostic challenge.

    Area of Science:

    • Medical Microbiology
    • Dermatology
    • Infectious Diseases

    Background:

    • Botryomycosis is a rare, chronic bacterial infection mimicking deep fungal infections.
    • It presents in visceral and cutaneous forms, with cutaneous being more prevalent.
    • Cutaneous botryomycosis typically manifests as solitary plaques with pustules.

    Observation:

    • Histological examination reveals bacterial colonies in a unique "bunch of grapes" pattern.
    • The Splendore-Hoeppli phenomenon, characterized by eosinophilic amorphous material, surrounds the bacterial colonies.
    • The study details a rare case of disseminated botryomycosis in an 83-year-old female.

    Findings:

    • The case presented disseminated botryomycosis, a rare manifestation of this bacterial infection.

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  • The histological "bunch of grapes" pattern and Splendore-Hoeppli phenomenon were key diagnostic features.
  • Disseminated disease indicates a more severe and widespread infection than typically observed.

    • Implications:

    • This case underscores the importance of considering botryomycosis in the differential diagnosis of chronic skin and visceral infections.
    • Recognizing the characteristic histological findings is crucial for accurate diagnosis.
    • Further research may elucidate optimal treatment strategies for disseminated forms of this rare infection.